Faculty Details for Dr. Tara C. Matise
Associate Professor
Contact Information
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Office: LSB 122 Phone: (732) 445-3125 Fax: (732) 445-1147 Email: matise@biology.rutgers.edu |
Life Sciences Building Rutgers University 145 Bevier Road Piscataway, NJ, 08854 |
Research
I head the Laboratory of Computational Genetics, in the Department of Genetics at Rutgers University. “Computational Genetics” represents my joint interests in genetics, computer science, statistical genetics, and bioinformatics. My research time is divided between basic research and developing tools and resources for use by the research community.
Some of my research projects are related to specific diseases, while other projects involve development of genome-wide tools and are disease-independent.
The focus of much of my research interest has been developing and applying tools for genome mapping, focusing on the construction of linkage and RH maps. The process of ordering markers on these two types of maps relies on statistical and heuristical methods, follows a stepwise algorithm, and is quite computationally intensive for large marker sets. I have written a computer program that is used for automated large-scale linkage and radiation hybrid mapping. MULTIMAP ( http://compgen.rutgers.edu/multimap ) is freely available to the genetics community and has been used in several genome-wide mapping projects in humans and other organisms (mouse, rat, dog).
With completion of sequencing of the human genome, we have incorporated marker physical positions into a novel mapping approach to create the Rutgers combined physical-linkage maps. These maps contain over 28,000 markers and represent the most comprehensive linkage maps that we are aware of ( http://compgen.rutgers.edu/maps ).
Another research project in my group focuses on meta-analysis of schizophrenia genetic studies to identify and characterize candidate gene regions. We are working to identify the most likely candidate genes within several schizophrenia candidate regions, and to prioritize these for further study. ( http://compgen.rutgers.edu/schiz )
I am embarking on a new area of research, to search for genes involved in female reproductive genetics - in other words, looking for genes that play a role in fertility. Ultimately I hope we will be able to use genetic markers to predict whether a woman is likely to proceed to the stage of infertility at a a pace that is average, faster than average, or slower than average. This information could be useful for improved family planning.
Additional information about my research can be found on my webpage at compgen.rutgers.edu.
updated July 8, 2008
Selected Publications
View Dr. Matise's publication list in PubMed
Matise, TC, Chen F, Chen W, De La Vega FM, Hansen M, He C, Hyland FCL, Kennedy GC, Kong X, Murray SS, Ziegla JS, Stewart WCL, Buyske S. 2007. Second-generation combined linkage-physical maps. Genome Research 17: 1783-1786.Buyske S, Bates ME, Gharani N, Matise TC, Tischfield JA, Manowitz P. 2006. Cognitive traits link to human chromosomal regions. Behav Genet. 36(1):65-76.
Kong, X, Matise TC. 2005. MAP-O-MAT: internet-based linkage mapping. Bioinformatics. 21(4):557-559.
Kong X, Murphy K, Raj T, He C, White PS, Matise TC. 2004. A combined linkage-physical map of the human genome. Am J Hum Genet 75:1143-1148.
White PS, Matise TC. 2004. Mapping Databases. In: Baxevanis A, Ouellette B eds. Bioinformatics: a practical guide to the analysis of genes and proteins, 3rd edition. John Wiley & Sons, New York, New York.
Kim DDY, Kim TTY, Walsh T, Kobayashi Y, Matise TC, Buyske S, Gabriel A. 2004. Widespread Alu-associated RNA editing in the human transcriptome. Genome Research 14:1719-1725.