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Li Liang
Li Liang
Assistant Research Professor
...
848-445-7214
Nelson C233
604 Allison Road, Piscataway, NJ 08854

Research

With a research interest in DNA repair, I am also active in applying next-generation sequencing technology to identify specific genomic changes in cancer that can be therapeutically targeted. As the director of CLIA-certified Clinical Genomics Laboratory at RUCDR Infinite Biologics I run a clinical laboratory focused on identifying genetic abnormalities that make tumors cancerous and help make precision medicine a reality for patients by providing comprehensive genomic profiles to oncologists to help them match their patients to targeted therapies.

Publications

  1. McClintick, J.N., Brooks, A.I., Deng, L., Liang, L., Wang, J.C., Kapoor, M., Xuei, X., Foroud, T., Tischfield, J.A., and Edenberg H.J. Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. Alcohol 48: 603-610, 2014.
  2. Carey, A.S., Liang, L.*, Edwards, J., Brandt, T., Mei, H., Sharp, A.J., Hsu, D.T., Newburger, J.W., Ohye, R.G., Chung, W.K., Russell, M.W., Rosenfeld, J.A., Shaffer, L.G., Parides, M.K., Edelmann, L., and Gelb, B.D. Effect of copy number variants on outcomes for infants with single ventricle heart defects. Circ. Cardiovasc. Genet. 6: 444-451, 2013. (*co-first author).
  3. Liu Y., Deng L., Nguyen S.C., Au C.L., Shao C., Tischfield J.A., and Liang, L. A human cell-based reporter detects microhomology-mediated end joining. Mutat Res. 731:140-144, 2012.
  4. Liang, L.*, Deng, L., Nguyen, S.C., Zhao, X., Maulion, C.D., Shao, C., and Tischfield, J.A. Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks. Nucleic Acids Res. 36: 3297-3310, 2008, (*corresponding author).
  5. Liang, L., Deng, L., Mendonca, M.S., Chen, Y., Stambrook, P.J., and Tischfield, J.A. X-rays induce distinct patterns of somatic mutation in fetal versus adult hematopoietic cells. DNA repair 6: 1380-1385, 2007.
  6. Liang, L., Mendonca, M.S., Deng, L., Nguyen, S.C., Shao, C., and Tischfield, J.A. Reduced apoptosis and increased deletion mutations in vivo in mice exposed to repeated ionizing irradiation. Cancer Res.67: 1910-1917, 2007.

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