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Christopher Rongo
Christopher Rongo
Professor - Vice Chair, Department of Genetics
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(848) 445-0955
(732) 445-5735
Waksman 33
Busch Campus Rutgers University 190 Frelinghuysen Rd. Piscataway, NJ, 08855

Research

Neuronal communication is the primary means by which our nervous system senses, interprets, remembers, and responds to the outside world and to our own internal physiology. Much of this communication occurs at chemical synapses, which are specialized signaling structures comprised of a presynaptic cell that releases neurotransmitters, and a postsynaptic cell that detects these neurotransmitters using receptor proteins. Our research is focused on glutamate receptors (GluRs), which detect glutamate, the major excitatory neurotransmitter in our brain. We are particularly interested in how GluRs are localized to synapses because such glutamate receptor cell biology plays an important role in synaptic communication, synaptic plasticity, and learning and memory. In addition, glutamate receptors are implicated in several diseases of the nervous system, and are a primary neurodegenerative agent activated by mechanical damage (e.g., traumatic injury) and by oxygen deprivation (e.g., stroke). Thus, a better understanding of these receptors will facilitate the diagnosis, treatment, and prevention of diseases attributable to neurodegeneration, and help us better understand the mechanisms behind learning and memory

Publications

Park, EC, Ghose P, Shao Z, Ye Q, Kang L, Xu XZ, Powell-Coffman JA, Rongo C.  2012.  Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism.. EMBO Journal. Epub ahead of print

Zhang, D, Isack NR, Glodowski DR, Liu J, Chen CC, Xu XZ, Grant BD, Rongo C.  2012.  RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway.. The Journal of Cell Biology. 196:85-101

Liu, G, Rogers J, Murphy CT, Rongo C.  2011.  EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan. EMBO J. 30:2990-3003.

Rongo, C.  2011.  Epidermal growth factor and aging: A signaling molecule reveals a new eye opening function. Aging. 3(9):1-10.

 

Lab Page

www.waksman.rutgers.edu/rongo/home
Christopher Rongo

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