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Jinchuan Xing
Jinchuan Xing
Assistant Professor
...
(848) 445-9663
(732) 445-1147
LSB 325
Life Sciences Building, 145 Bevier Road Piscataway, NJ, 08854

Research

The long-term research interest of my laboratory is to understand the mechanisms and consequences of human genomic variation, with a focus on mobile DNA elements, and human disease. We will combine computational and experimental tools to perform genome-wide analyses on human genomic variation. Current research in my lab includes three major areas: understanding mobile element biology, investigating human demographic history and population diversity, and identifying disease-causing genes using genome-wide data.

Publications

Witherspoon, D. J., Y. Zhang, J. Xing, W. S. Watkins, H. Ha,  M. A. Batzer and L. B. Jorde (2013) Mobile Element Scanning (ME-Scan) identifies thousands of novel Alu insertions in diverse human populations. Genome Research 23(7):1170-81

Xing, J., D. J. Witherspoon, and L. B. Jorde (2013) Mobile element biology – new possibilities with high-throughput sequencing. Trends in Genetics 29(5):280-9

Kim, W. , D. Londono, L. Zhou, J. Xing, A. Nato, A. Musolf, T. C. Matise, S. J. Finch, and D. Gordon (2012) Single variant and multi-variant trend tests for genetic association with next generation sequencing that are robust to sequencing error. Human Heredity 74:172-183

The 1000 Genomes Project Consortium (2012) An integrated map of genetic variation from 1,092 human genomes. Nature 491:56–65

Stewart, C.*, D. Kural*, M. P. Stromberg*, J. A. Walker, M. K. Konkel, A. M. Stutz, A. E. Urban, F. Grubert, H. Y. Lam, W.-P. Lee, M. Busby, A. R. Indap, E. Garrison, C. Huff, J. Xing, M. P. Snyder, L. B. Jorde, M. A. Batzer, J. O. Korbel, G. T. Marth, and 1000 Genomes Project (2011) A comprehensive map of mobile element insertion polymorphisms in humans. PLoS Genetics 7(8): e1002236.

Yandell, M., C. D. Huff, H. Hu, M. Singleton, B. Moore, J. Xing, L. B. Jorde, and M. G. Reese (2011) A probabilistic disease-gene finder for personal genomes. Genome Research 21(9):1529-42

Rope, A. F., K. Wang, R. Evjenth, J. Xing, J. J. Johnston, J. J. Swensen, W. E. Johnson, B. Moore, C. D. Huff, L. M. Bird, J. C. Carey, J. M. Opitz, C. A. Stevens, T. Jiang, C. Schank, H. D. Fain, R. Robison, B. Dalley, S. Chin, S. T. South, T. J. Pysher, L. B. Jorde, H. Hakonarson, J. R. Lillehaug, L. G. Biesecker, M. Yandell, T. Arnesen, and G. J. Lyon (2011) Using VAAST to identify an X-Linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency. American Journal of Human Genetics 89(1):28-43.

Xing, J., W. S. Watkins, Y. Hu, C. D. Huff, A. Sabo, D. M. Muzny, M. J. Bamshad, R. A. Gibbs, L. B. Jorde, and F. Yu (2010) Inference of human expansion in Eurasia and genetic diversity in India. Genome Biology 11:R113

The 1000 Genomes Project Consortium (2010) A map of human genome variation from population scale sequencing. Nature 467:1061-1073

Xing, J., W. S. Watkins, A. Shlien, E. Walker, C. D. Huff, D. J. Witherspoon, Y. Zhang, T. S. Simonson, R. B. Weiss, J. D. Schiffman, D. Malkin, S. R. Woodward and L. B. Jorde (2010) Toward a more Uniform Sampling of Human Genetic Diversity: A Survey of Worldwide Populations by High-density Genotyping. Genomics 96:199¨C210

Witherspoon, D. J., J. Xing, Y. Zhang, W. S. Watkins, M. A. Batzer and L. B. Jorde (2010) Mobile element scanning (ME-Scan) by targeted high-throughput sequencing. BMC Genomics 11(1):410

Simonson, T. S., Y. Yang, C. D. Huff, H. Yun, G. Qin, D. J. Witherspoon, Z. Bai, F. R. Lorenzo, J. Xing, L. B. Jorde, J. T. Prchal, and R. Ge (2010) Genetic Evidence for High-Altitude Adaptation in Tibet. Science 329(5987):72-5

Huff, C. D., J. Xing, A. R. Rogers, D. J. Witherspoon, and L. B. Jorde (2010) Mobile elements reveal small population size in the ancient ancestors of Homo sapiens. Proceedings of the National Academy of Sciences, USA 107:2147-2152

Xing, J., Y. Zhang, K. Han, A. H. Salem, S. K. Sen, C. D. Huff, Q. Zhou, E. F. Kirkness, S. Levy, M.A. Batzer, and L. B. Jorde (2009) Mobile elements create structural variation: analysis of a complete human genome. Genome Research 19(9):1516-26

Xing, J., W. S. Watkins, D. J. Witherspoon, Y. Zhang, S. L. Guthery,?R. Thara, B. J. Mowry, K. Bulayeva, R. B. Weiss, and L. B. Jorde (2009) Fine-Scaled Human Genetic Structure Revealed by SNP Microarrays. Genome Research 19(5):815-25

Xing, J., W. S. Watkins, Y. Zhang, D. J. Witherspoon, and L. B. Jorde (2008) High Fidelity of Whole-Genome Amplified DNA on High-Density Single Nucleotide Polymorphism Arrays. Genomics 92(6):452-6

Xing, J., D. J. Witherspoon, W. S. Watkins, Y. Zhang, W. Tolpinrud and L. B. Jorde. (2008) HapMap tagSNP transferability in multiple populations: general guidelines. Genomics 92:41-51

Lab Page

xinglab.genetics.rutgers.edu
Xing Lab of Genomics

Upcoming Seminars & Events

Sort DateDate/TimeTitleHostDescriptionLocation
20171204.120000Mon, Dec 04, 2017 @ 12:00pm
Department of Genetics Seminar SeriesGenetics/Human Genetics InstituteSpeaker: Dr. Peter Andolfatto
Dr. Peter Andolfatto/ Princeton University/ Princeton, NJ
Web Site
Life Sciences Building
Auditorium :
145 Bevier Road, Piscataway , NJ
20180402.120000Mon, Apr 02, 2018 @ 12:00pm
Department of Genetics Seminar Series Genetics/Human Genetics InstituteSpeaker: Dr. Jinchuan Xing
Dr. Ting Wang/ Washington University/ St. Louis, MO
Web Site
Life Sciences Building
Auditorium :
145 Bevier Road, Piscataway , NJ

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