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Karen Schindler
Karen Schindler
Assistant Professor
...
(848) 445-2563
(732) 445-1147
LSB 222
Life Sciences Building Rutgers University 145 Bevier Rd Piscataway, NJ, 08854

Research

Haploid gametes (sperm and eggs) are generated by meiosis and are essential for sexual reproduction. In females, meiosis is highly error-prone as ~5-20% of a young, healthy woman’s eggs contain an abnormal number of chromosomes (aneuploid). Aneuploidy is the leading cause of infertility, miscarriage and, in the case of live birth, developmental disorders such as Down Syndrome. Little is known, however, about how meiosis in females is regulated and why it is so prone to chromosome segregation mistakes. Research in our group uses the mouse oocyte model to understand how signal transduction networks, specifically at the level of protein kinases and protein phosphatases, regulate female meiosis.

Publications

Balboula, AZ, and Schindler, K. 2014. Selective Disruption of Aurora C Kinase Reveals Distinct Functions From Aurora B Kinase During Meiosis in Mouse Oocytes. Plos Genetics.10(2):e1004194. 

Balboula, AZ, Stein, P, Schultz, RM and Schindler, K. 2014. Knockdown of RBBP7 unveils a requirement of histone deacetylation for CPC function in mouse oocytes. Cell Cycle. 13(4):600-11. 

Oh JS, Susor A, Schindler K, Schultz RM, Conti M. 2013. Cdc25A activity is required for the metaphase II arrest in mouse oocytes. Journal of Cell Science. 126(Pt 5): 1081-5. 

Schindler K*, Davydenko O*, Fram B, Lampson MA, Schultz RM. (2012) Maternally-recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte maturation and early development. PNAS 109(33): E2215-22.

Schindler K. (2011). Protein kinases and protein phosphatases that regulate meiotic maturation in mouse oocytes. In: Cell Cycle in Development. (v. 53 of Results and Problems in Cell Differentiation) (Ed. by J. Kubiak). Springer, pg. 309-341.

Stein P, Schindler K. (2011). Mouse oocyte microinjection, maturation and ploidy assessment. Journal of Visualized Experiments 53, 2851.

Chiang T, Duncan FE, Schindler K, Schultz RM, Lampson MA. (2010). Weakened centromere cohesion is the primary cause of age-related aneuploidy in oocytes. Current Biology 20,1522-8.

Buffone MG*, Schindler K*, and Schultz RM. (2009). Over-expression of CDC14B causes mitotic arrest and inhibits zygotic genome activation in mouse preimplantation embryos. Cell Cycle 8, 3904-3914.

Shuda K*, Schindler K*, Ma J, Schultz RM, Donovan PJ. 2009. Aurora Kinase B modulates chromosome alignment in mouse oocytes. Molecular Reproduction and Development 76, 1094-105.

Schindler K, Schultz RM. (2009). The CDC14A phosphatase regulates oocyte maturation in mouse. Cell Cycle 8, 1-9.

Schindler K, Schultz RM. (2009). CDC14B acts through FZR1 (CDH1) to prevent meiotic maturation of mouse oocytes. Biology of Reproduction 80, 795-803.

Moore M, Shin, ME, Bruning A, Schindler K, Vershon A, Winter E. (2007). Arg-Pro-X-Ser/Thr is a consensus phosphoacceptor sequence for the meiosis-specific Ime2 protein kinase in Saccharomyces cerevisiae. Biochemistry 46, 271-8.

Krishnamoorthy T, Chen X, Govin J, Cheun, WL, Dorsey J, Schindler K, Winter E, Allis CD, Guacci V, Khochbin S, Fuller MT, Berger SL. (2006). Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis. Genes and Development 20, 2580-92.

Schindler K, Winter E. (2006). Phosphorylation of Ime2p regulates meiotic progression in Saccharomyces cerevisiae. Journal of Biological Chemistry 281, 18307-16.

Schindler K, Benjamin, KR, Martin A, Boglioli A, Herskowitz I, Winter E. (2003). The Cdk-activating kinase Cak1p promotes meiotic S phase through Ime2p. Molecular and Cellular Biology 23, 8718-28.

Schaber M, Lindgren A, Schindler K, Bungard D, Kaldis P, Winter E. (2002). CAK1 promotes meiosis and spore formation in Saccharomyces cerevisiae in a CDC28-independent fashion. Molecular and Cellular Biology 22, 57-68.

Lab Page

genfaculty.rutgers.edu/schindler
Karen Schindler

Upcoming Seminars & Events

Sort DateDate/TimeTitleHostDescriptionLocation
20171002.120000Mon, Oct 02, 2017 @ 12:00pm
"RNA variants in male germ cells: a new layer of developmental regulation"Genetics/Human Genetics InstituteSpeaker: Dr. Elizabeth Snyder
Dr. Elizabeth Snyder / Department of Animal Science/ Rutgers University/ New Brunswick, NJ
Web Site
Life Sciences Building
Auditorium:
145 Bevier Road, Piscataway, NJ
20171009.203000Mon, Oct 09, 2017 @ 8:30pm
What is genetic counselingGenetics/Human Genetics InstituteSpeaker: Professor Jessica Joines
The Association of Undergraduate Geneticists Presents: The Career of Genetic Counseling
Web Site
Life Sciences Building
Auditorium:
145 Bevier Road, Piscataway, NJ

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