|Life Sciences Building Rutgers University 145 Bevier Road Piscataway, NJ, 08854|
Perekatt AO, Shah P, Cheung S, Jariwala N, Wu A, Gandhi V, Kumar N, Fang Q, Patel N, Chen L, Joshi S, Zhou A, Taketo MM, Xing J, White E, Gao N, Gatza M, Verzi MP. SMAD4 suppresses WNT-driven dedifferentiation and oncogenesis in the differentiated gut epithelium. Under revision at Cancer Research.
Srivillibhuthur M, Warder B, Toke N, Shah P, Feng Q, Gao N, Bonder E, Verzi MP. TFAM is required for maturation of the fetal and adult intestinal epithelium. Dev. Biol. in press
Tong K, Pellon-Cardenas O, Sirihorochai VR, Warder BN, Kothari OA, Perekatt AO, Fokas EE, Fullem RL, Zhou A, Thackray JK, Tran H, Zhang L, Xing J, Verzi MP. Degree of Tissue Differentiation Dictates Susceptibility to BRAF-Driven Colorectal Cancer. Cell Reports. 2017.
Chatterjee I, Kumar A, Castilla-Madrigal RM, Pellon-Cardenas O, Gill RK, Alrefai WA, Borthakur A, Verzi M, and Dudeja PK. CDX2 upregulates SLC26A3 gene expression in intesitnal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2017.
Kumar N, Srivillibhuthur M, Joshi S, Walton KD, Zhou A, Faller WJ, Perekatt AO, Sansom OJ, Gumucio DL, Xing J, Bonder EM, Gao N, White E, Verzi MP. A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis. Development. 2016.
Tsai YH, Hill DR, Kumar N, Huang S, Chin AM, Dye BR, Nagy MS, Verzi MP, Spence JR. LGR4 and LGR5 Function Redundantly During Human Endoderm Differentiation. CMGH. 2016
Lund PK, Verzi MP. Singling Out Intestinal Epithelial Stem Cells.Gastroenterology. 2016
San Roman AK, Aronson BE, Krasinski SD, Shivdasani RA, Verzi MP.Transcription Factors GATA4 and HNF4A Control Distinct Aspects of Intestinal Homeostasis in Conjunction With the Transcription Factor CDX2. J Biol Chem. 2015.
Das S, Yu S, Sakamori R, Vedula P, Qiang F, Flores J, Hoffman A, Fu J, Stypulkowski E, Rodriguez A, Dobrowolski R, Harada A, Hsu W, Bonder EM, Verzi MP, Gao N, Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche. Development. May, 2015.
Chahar S, Gandhi V, Yu S, Desai K, Cowper-Sal-lari R, Kim Y, Perekatt AO, Kumar N, Thackray JK, Musolf A, Kumar N, Hoffman A, Londono D, Vazquez BN, Serrano L, Shin H, Lupien M, Gao N, Verzi MP. Chromatin profiling reveals regulatory network shifts and a protective role for HNF4A during colitis. Mol Cell Biol. Sept, 2014. Featured on cover.
Perekatt AO, Valdez MJ, Davila M, Hoffman A, Bonder EM, Gao N, Verzi MP. YY1 is indispensable for Lgr5+ intestinal stem cell renewal. PNAS. 2014. May 27;111(21):7695-700. selected as a Faculty1000 paper.
Kim TH, Li F, Ferreiro-Neira I, Ho L, Luyten A, Nalapareddy K, Long H, Verzi MP, Shivdasani RA. Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity. Nature. Jan 12, 2014.
Sakamori R, Yu S, Zhang X, Hoffman A, Sun J, Das S, Vedula P, Li G, Fu J, Walker F, Yang CS, Hsu W, Yu DH, Shen L, Rodriguez AJ, Taketo MM, Bonder EM, Verzi MP, Gao N. CDC42 inhibition suppresses progression of incipient intestinal tumors. Cancer Res. Oct, 1, 2014.
Aronson BE, Rabello Aronson S, Berkhout RP, Chavoushi SF, He A, Pu WT, Verzi MP, Krasinski SD. GATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27. Biochim Biophys Acta. 2014 May 27
Verzi MP, Shin H, San Roman AK, Liu XS, Shivdasani RA. Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding. Mol Cell Biol. 2013 Jan;33(2):281-92
Beuling E, Aronson BE, Tran LM, Stapleton KA, ter Horst EN, Vissers LA, Verzi MP, Krasinski SD. GATA6 is required for proliferation, migration, secretory cell maturation, and gene expression in the mature mouse colon. Mol Cell Biol. 2012 Sep;32(17):3392-402
Verzi MP, Shin H, Ho LL, Liu XS, Shivdasani RA. Essential and redundant functions of caudal family proteins in activating adult intestinal genes. Mol Cell Biol. 2011 May;31(10):2026-39.
If the intestinal epithelium was unraveled it would be a one-cell-thick layer with enough surface area to cover a tennis court. This thin layer selectively absorbs nutrients while repelling toxins and pathogens. Because it’s a dirty job, the entire epithelium is shed and replenished continuously (much like our skin) with the entire epithelium replaced every few days. High exposure to noxious substances coupled with high rates of proliferation make this epithelial layer susceptible to both cancer and inflammatory disease. Intestinal diseases are among the most prevalent maladies in our society.