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Kevin Chen
Kevin Chen
Associate Professor
...
(848) 445-7196
(732) 445-1147
Nelson C225
604 Allison Road, Piscataway, NJ 08854-8082

Research

Our group develops computational methods for problems at the interface of molecular biology and evolution. Our major biological focus is to understand the function and evolution of small regulatory RNAs such as microRNAs and Piwi-interacting RNAs (piRNAs) in animals. We also have several close collaborations with experimental groups to validate our computational predictions in the lab.

Publications

    L. Diao and K. Chen. Local ancestry corrects for population structure in S. cerevisiae genome-wide association studies. In press, Genetics, December 2012.


    D. W. Gould, S. Lukic and K. Chen. Selective constraint on copy number variation in human Piwi-interacting RNA loci. PLoS ONE, 7(10): e46611, 2012.


    R. S. Roy, K. Chen, A. M. Sengupta and A. Schliep. SLIQ: Simple linear inequalities for efficient contig scaffolding. Journal of Computational Biology, 19(10): 1162-1175, 2012.


    M. S. Kumar and K. Chen. Evolution of animal Piwi-interacting RNAs and prokaryotic CRISPRs. Briefings in Functional Genomics, 11(4):277-88, 2012.


      S. Lukic and K. Chen. Human piRNAs are under selection in Africans and repress transposable elements. Molecular Biology and Evolution, 28:3061-3067, 2011.


      S. Lukic, J. Hey and K. Chen. Non-equilibrium allele frequency spectra via spectral methods. Theoretical Population Biology, 79:203-219, 2011


      J-S. Yang, M. D. Phillips, D. Betel, P. Mu, C. Sander, A. Ventura, A. C. Siepel, K. Chen*, E. C. Lai*. Widespread regulatory activity of vertebrate microRNA* species. RNA 17:312-326, 2011. (*co-corresponding authors)

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