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• 
• Tetsuya Nakamura
• Position: Assistant Professor
• Research Focus: Revealing the genetic mechanisms of the fish diversity and their contribution to the fish-to-tetrapod transition
• Subset Area: Genetic Mechanisms | Evolution
• Click for Lab Website
• Email: tn241@rutgers.edu
• Phone: (848) 445-7191
• Address: Life Sciences Bldg. Rutgers University 145 Bevier Road Piscataway, NJ, 08854
• Office: LSB-224
• Fax: (732) 445-1147
• biography:

  2002 B.S. Osaka University, Osaka, Japan, Bioengineering

  2007 Ph.D. Osaka University, Osaka, Japan, Developmental Biology

  2007-2008 Postdoctoral Scholar, Osaka University, Japan

  2008-2012 Assistant Professor, Osaka University, Japan

  2012-2017 Postdoctoral Scholar, The University of Chicago, Chicago, IL

  2018- Assistant Professor, Department of Genetics, Rutgers University

• Research:

  Bridging functional genomics, experimental embryology, comparative anatomy, and paleontology, our research seeks to answer long-standing and classical questions of vertebrate evolution. Our long-term research goal is to reveal and understand the evolutionary and developmental mechanisms of the fish diversity and its contribution to vertebrate major transitions. As new genomic and imaging technologies extend their utility to model and non-model organisms alike, these fundamental problems become within our reach. 

• Publications:

  Wood T and Nakamura T
  Problems in Fish-to-Tetrapod Transition: Genetic Expeditions into Old Specimens
  Front. Cell Dev. Biol. 2018

  Letelier J, Calle-Mustienes E, Pieretti J, Naranjo S, Maeso I, Nakamura T, Pascual-Anaya J, Shubin NH, Schneider I, Martinez-Morales JR & Gómez-Skarmeta JL.  A conserved Shh cis-regulatory module highlights a common developmental origin of unpaired and paired fins. Nature Genetics. 2018 

  Nakamura T, Gerhke AR, Lemberg J, Szymaszek J, Shubin NH. Digits and fin rays share common developmental histories. Nature. 2016 Aug 17;537(7619):225-228                                                                

  Inaba Y, Shinohara K, Bottled Y, Nabeshima R, Takaoka K, Ajima R, Lamri L, Takeda H, Saga Y, Nakamura T, Hamada H. Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrcc6. Genes Cells. 2016 Jul;21(7):728-39.

  Braasch I, Gehrke AR, Smith JJ, Kawasaki K, Manousaki T, Pasquier J, Amores A, Desvignes T, Batzel P, Catchen J, Berlin AM, Campbell MS, Barrell D, Martin KJ, Mulley JF, Ravi V, Lee AP, Nakamura T et al. The spotted gar genome illuminates vertebrate evolution and facilitated human-teleost comparisons. Nature Genetics. 2016 Apr;48(4):427-37                                                                

  Nakamura T, Klomp J, Pieretti J., Schneider I.,Gerhke AR., Shubin NH. Molecular mechanisms underlying the exceptional adaptations of batoid fins. Proc Natl Acad Sci U S A. 2015 Dec 29; 112(52):15940-5.  

  Pieretti J, Gehrke AR, Schneider I, Adachi N, Nakamura T, Shubin NH. Organogenesis in deep time: A problem in genomics, development, and paleontology. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):4871-6
   
  Gehrke AR, Schneider I, de la Calle-Mustienes E, Tena JJ, Gomez-Marin C, Chandran M, Nakamura T, Braasch I, Postlethwait JH, Gómez-Skarmeta JL, Shubin NH. Deep conservation of wrist and digit enhancers in fish. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):803-8

  Dong F, Shinohara K, Botilde Y, Nabeshima R, Asai Y, Fukumoto A, Hasegawa T, Matsuo M, Takeda H, Shiratori H, Nakamura T and Hamada H. Pih1d3 is required for cytoplasmic pre-assembly of axonemal dynein in mouse sperm. Journal of Cell Biology, 2014 Jan 20;204(2):203-13

  Inácio JM, Marques S, Nakamura T, Shinohara K, Meno C, Hamada H, Belo JA. The dynamic right-toleft translocation of Cerl2 is involved in the regulation and termination of Nodal activity in the mouse node. PLoS One. 2013. 8(3):e60406

   Nakamura T, Saito D, Kawasumi A, Shinohara K, Asai Y, Takaoka K, Dong F, Takamatsu A, Belo JA, Mochizuki A*, Hamada H. Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA. Nature Communications. 2012;3:1322.

   Lei Z, Maeda T, Tamura A, Nakamura T, Yamazaki Y, Shiratori H, Yashiro K, Tsukita S, Hamada H. EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins. Developmental Biology. 2012 Nov 15;371(2):136-45.

  Nakamura T, Hamada H. Left-right patterning: conserved and divergent mechanisms. Development. 2012 Sep;139(18):3257-62. 

  Kawasumi.A, Nakamura T, Iwai N, Yashiro K, Saijoh Y, Belo J, Shiratori H, Hamada H. Left-right asymmetry of Nodal activity in the node is translated into left-right asymmetry in the lateral plate of mouse embryos. Developmental Biology, 2011, 2011 May 15;353(2):321-30.   

  Tanaka C, Sakuma R, Nakamura T, Hamada H, Saijoh Y. Long-range action of Nodal requires interaction with GDF1. Genes and Development. 2007 Dec 15;21(24):3272-82.

  Nakamura T, Mine N, Nakaguchi E, Mochizuki A, Yamamoto M, Yashiro K, Meno C, Hamada H. Generation of robust left-right asymmetry in the mouse embryo requires a self- enhancement and lateral-inhibition system. Developmental Cell, 11, 495-504, 2006

  Saijoh Y, Oki S, Tanaka C, Nakamura T, Adachi H, Yan YT, Shen MM, Hamada H. Two nodal-responsive enhancers control left-right asymmetric expression of Nodal.  Developmental Dynamics, 232(4);1031-1036; 2005

  Takagi M, Nakamura T, Matsuda C, Hattori T, Wakitani S, Yoshida T. In vitro proliferation of human bone marrow mesenchymal stem cells employing donor serum and basic fibroblast growth factor. Cytotechnology, 43:89-96,2003

   

   

   

• Publications PubMed:

  
  

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Last Updated: Thursday, 13 October 2022 10:50